Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Cancer immunotherapies that engage immune cells to fight against tumors are proving to be
powerful weapons in combating cancer and are becoming increasingly utilized in the clinics …

The substantial advances attained by checkpoint blockade immunotherapies have driven an
expansion in the approaches used to promote T cell access to the tumor microenvironment …

Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor
microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages …

Simple Summary Macrophages are a major component of the pancreatic tumor
microenvironment, and their increased abundance is associated with poor patient survival …

Simple Summary Tumor-associated macrophages (TAMs) coinhabit the tumor
microenvironment with cancer, immune, and stromal cells. They undermine the immune …

ABSTRACT TNF Receptor Superfamily (TNF-R-SF) signaling is a structurally well-defined
event that requires proper receptor clustering and trimerization. While the TNF-SF ligands …

Simple Summary Immune checkpoint blockade has provided durable clinical responses in a
number of human malignancies, but not in patients with pancreatic cancer. Efforts to …

We investigate how myeloid subsets differentially shape immunity to pancreatic ductal
adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition …

Background Achieving robust responses with adoptive cell therapy for the treatment of the
highly lethal pancreatic ductal adenocarcinoma (PDA) has been elusive. We previously …