Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism. Mammals
cannot synthesize folate and depend on supplementation to maintain normal levels. Low …

Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

Abstract The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) is involved in
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …

Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of
homocysteine–a cytotoxic sulfur-containing amino acid that can induce DNA strand …

Spina bifida results from failure of fusion of the caudal neural tube, and is one of the most
common malformations of human structure. The causes of this disorder are heterogeneous …

Folate is a water-soluble B-vitamin and enzymatic cofactor that is necessary for the synthesis
of purine and thymidine nucleotides and for the synthesis of methionine from homocysteine …

The influence of folate nutritional status on various pregnancy outcomes has long been
recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal …

Neurulation occurs during the early embryogenesis of chordates, and it results in the
formation of the neural tube, a dorsal hollow nerve cord that constitutes the rudiment of the …

The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to
DNA synthesis or to homocysteine (Hcy) remethylation. The common MTHFR C677T …

Neural tube defects (NTDs) are common, severe congenital malformations whose causation
involves multiple genes and environmental factors. Although more than 200 genes are …