Radical difunctionalizations of alkenes constitute an efficient method for the construction of
complex organic molecules. This synopsis focuses on visible-light catalysis, a recent and …

Electrophilic trifluoromethylation reactions have been the latest approach to achieve the
fluoroalkylation of compounds with newly‐discovered reagents, such as the Togni's (1 …

The Minisci alkylation is useful to functionalize aromatics via alkyl radical addition. Current
approaches to prepare alkyl radicals follow either oxidative or reductive pathways from …

A general approach for preparation of two types of polyfunctionalized 3-
trifluoromethylpyrazoles is reported. The protocol comprises (3+ 2)-cycloaddition of the in …

A novel continuous‐flow approach for the synthesis of fluoroalkyl‐substituted
diazomethanes has been developed. Utilizing a cheap, self‐made microreactor fluoroalkyl …

A copper-mediated synthesis of 4-(trifluoromethyl) pyrazoles is described. In one step from
readily accessible α, β-alkynic tosylhydrazones, a remarkable domino sequence of …

Abstract Difluorodiazoethane (CF2HCHN2) is a small reactive diazoalkane. Its synthesis has
been pursued since the 1970s, although only in the past three years have considerable …

We herein describe a three-component interrupted click reaction to synthesize novel 5-
pentafluoroethyl 1, 2, 3-triazoles in one step from readily available terminal alkynes and …

The trifluoromethyl (CF3) group is an advantageous structural motif in various biologically
active molecules as well as materials, which is depicted by steadily increasing demand from …

An elemental tellurium mediated synthesis of 2-(trifluoromethyl) oxazoles from the reaction
of acetophenone oxime acetates with trifluoroacetic anhydride has been developed. This …