Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

Complement C4, a key molecule in the complement system that is one of chief constituents
of innate immunity for immediate recognition and elimination of invading microbes, plays an …

Mobile DNAs, also known as transposons or 'jumping genes', are widespread in nature and
comprise an estimated 45% of the human genome. Transposons are divided into two …

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes).
Through comparison with the human genome, we have generated a largely complete …

More than 90% of cases of congenital adrenal hyperplasia (CAH, the inherited inability to
synthesize cortisol) are caused by 21-hydroxylase deficiency. Females with severe, classic …

The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …

▪ Abstract L1 retrotransposons comprise 17% of the human genome. Although most L1s are
inactive, some elements remain capable of retrotransposition. L1 elements have a long …