Nicotine chemistry, metabolism, kinetics and biomarkers
NL Benowitz, J Hukkanen, P Jacob III - Nicotine psychopharmacology, 2009 - Springer
Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a
pharmacological aid to smoking cessation. The absorption, distribution and disposition …
pharmacological aid to smoking cessation. The absorption, distribution and disposition …
[HTML][HTML] Apoptosis and acute kidney injury
A Havasi, SC Borkan - Kidney international, 2011 - Elsevier
Improved mechanistic understanding of renal cell death in acute kidney injury (AKI) has
generated new therapeutic targets. Clearly, the classic lesion of acute tubular necrosis is not …
generated new therapeutic targets. Clearly, the classic lesion of acute tubular necrosis is not …
Metabolism and disposition kinetics of nicotine
J Hukkanen, P Jacob, NL Benowitz - Pharmacological reviews, 2005 - ASPET
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …
smoking cessation, a potential medication for several diseases, and a useful probe drug for …
Xenobiotic, bile acid, and cholesterol transporters: function and regulation
CD Klaassen, LM Aleksunes - Pharmacological reviews, 2010 - ASPET
Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …
Renal drug transporters and drug interactions
Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”)
AR Green, AO Mechan, JM Elliott, E O'Shea… - Pharmacological …, 2003 - ASPET
The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …
a popular recreational drug among young people, particularly those involved in the dance …
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin
Metformin, a biguanide, is widely used as an oral hypoglycemic agent for the treatment of
type 2 diabetes mellitus. The purpose of the present study was to investigate the role of …
type 2 diabetes mellitus. The purpose of the present study was to investigate the role of …
Gene expression levels and immunolocalization of organic ion transporters in the human kidney
H Motohashi, Y Sakurai, H Saito… - Journal of the …, 2002 - journals.lww.com
Renal excretion of organic anions and cations is mediated by the organic ion transporter
family (SLC22A). In this study, the mRNA levels of the organic ion transporters were …
family (SLC22A). In this study, the mRNA levels of the organic ion transporters were …
Nephrotoxicity of anticancer treatment
J Małyszko, K Kozłowska, L Kozłowski… - Nephrology Dialysis …, 2017 - academic.oup.com
Severe adverse systemic drug events occur commonly as a result of treatment of cancer
patients. Nephrotoxicity of chemotherapeutic agents remains a significant complication …
patients. Nephrotoxicity of chemotherapeutic agents remains a significant complication …
Impact of drug transporter studies on drug discovery and development
N Mizuno, T Niwa, Y Yotsumoto, Y Sugiyama - Pharmacological reviews, 2003 - ASPET
Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and
brain, and play key roles in drug absorption, distribution, and excretion. The information on …
brain, and play key roles in drug absorption, distribution, and excretion. The information on …