Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a
pharmacological aid to smoking cessation. The absorption, distribution and disposition …

Improved mechanistic understanding of renal cell death in acute kidney injury (AKI) has
generated new therapeutic targets. Clearly, the classic lesion of acute tubular necrosis is not …

Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

Metformin, a biguanide, is widely used as an oral hypoglycemic agent for the treatment of
type 2 diabetes mellitus. The purpose of the present study was to investigate the role of …

Renal excretion of organic anions and cations is mediated by the organic ion transporter
family (SLC22A). In this study, the mRNA levels of the organic ion transporters were …

Severe adverse systemic drug events occur commonly as a result of treatment of cancer
patients. Nephrotoxicity of chemotherapeutic agents remains a significant complication …

Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and
brain, and play key roles in drug absorption, distribution, and excretion. The information on …