Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

The neurotransmitter dopamine (DA) has a long association with normal functions such as
motor control, cognition, and reward, as well as a number of syndromes including drug …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains
circadian rhythms by synchronization to environmental cues and is involved in diverse …

Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …

Drugs activating 5-hydroxytryptamine 2C receptors (5-HT 2C Rs) potently suppress appetite,
but the underlying mechanisms for these effects are not fully understood. To tackle this …

The claustrum is among the most enigmatic of all prominent mammalian brain structures.
Since the 19th century, a wealth of data has amassed on this forebrain nucleus. However …

5-HT2 receptors are G-protein coupled receptors that currently comprise threesubtypes: 5-
HT2A, 5-HT2B and 5-HT2C receptors. The subtypes are related in theirmolecular structure …

Although the cardinal manifestations of Parkinson's disease (PD) are attributed to a decline
in dopamine levels in the striatum, a breadth of non-motor features and treatment-related …

Background Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal
tract characterized by abdominal discomfort, pain and changes in bowel habits, often …

Lorcaserin (APD356) is a potent, selective 5‐HT2C agonist with∼ 15‐fold and 100‐fold
selectivity vs. 5‐HT2A and 5‐HT2B receptors, respectively. This study evaluated the safety …