Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers
and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to …

Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …

In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

Prediction of local exposure following inhalation of a locally acting pulmonary drug is central
to the successful development of novel inhaled medicines, as well as generic equivalents …

Ideal controlled pulmonary drug delivery systems provide sustained release by retarding
lung clearance mechanisms and efficient lung deposition to maintain therapeutic …

Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous
particles can effectively enhance the aerosolization performance and bioavailability of …

Pulmonary drug delivery has attracted considerable attention in recent years. However, it is
still a major challenge to deliver poorly water-soluble drugs to lungs with good solubility and …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

Although the mucus layer is the first biological barrier encountered by inhaled drugs upon
their deposition in the upper airways, its potential impact on drug dissolution and absorption …

Natural ingredients have many applications in modern medicine and pharmaceutical
projects. However, they often have low solubility, poor chemical stability, and low …