Cellular senescence is a stress response, which can be evoked in all type of somatic cells
by different stimuli. Senescent cells accumulate in the body and participate in aging and …

Background: For more than a century, diagnostic pathologists have used morphologic
abnormalities of the nucleus as essential diagnostic features to distinguish benign from …

Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …

Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

Apolipoprotein E (APOE) is a component of lipoprotein particles that function in the
homeostasis of cholesterol and other lipids. Although APOE is genetically associated with …

Quantifying the mechanical response of the biological milieu (such as the cell's interior) and
complex fluids (such as biomolecular condensates) would enable a better understanding of …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Histone variants represent chromatin components that diversify the structure and function of
the genome. The variants of H2A, primarily H2A. X, H2A. Z and macroH2A, are well …

The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects,
regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its …