Accumulating evidence shows that deregulation of fatty acid (FA) metabolism is associated
with the development of cancer. Long-chain acyl-coenzyme A synthases (ACSLs) are …

Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as
a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been …

Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
developing sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …

The fact that the identity of the cells that initiate metastasis in most human cancers is
unknown hampers the development of antimetastatic therapies. Here we describe a …

Cold-induced thermogenesis (CIT) is widely studied as a potential avenue to treat obesity,
but a thorough understanding of the metabolic changes driving CIT is lacking. Here, we …

All homeotherms use thermogenesis to maintain their core body temperature, ensuring that
cellular functions and physiological processes can continue in cold environments,,. In the …

The heart has both the greatest caloric needs and the most robust oxidation of fatty acids
(FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake …

Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but
regulation of lymphatic vessel function and its link to disease remain unclear. Here we show …

Rationale: A hallmark of chronic inflammatory disorders is persistence of proinflammatory
macrophages in diseased tissues. In atherosclerosis, this is associated with dyslipidemia …

Ovarian cancer is the most lethal gynecological cancer. In spite of recent advances, clinical
outcomes remain poor, urgently needing novel therapeutic approaches. Growing evidence …