Humans have over 70 potassium channel genes, but only some of these have been linked
to disease. In this respect, the KCNQ family of potassium channels is exceptional: mutations …

Aging is a natural consequence of a society developing process. Although many adults
retain good hearing as they aging, hearing loss related with age–presbycusis which can …

Normal hearing depends on sound amplification within the mammalian cochlea. The
amplification, without which the auditory system is effectively deaf, can be traced to the …

The pharmacologic profile of retigabine [RTG (international nonproprietary name);
ezogabine, EZG (US adopted name)], is different from all currently approved antiepileptic …

Potassium channels play important roles in vital cellular signaling processes in both
excitable and nonexcitable cells. Over 50 human genes encoding various K+ channels have …

KCNQ genes encode a growing family of six transmembrane domains, single pore-loop, K+
channel α-subunits that have a wide range of physiological correlates. KCNQ1 (KvLTQ1) is …

Mutations in the gene encoding the K+ channel KCNQ2 cause neonatal epilepsy and
myokymia, indicating that KCNQ2 regulates the excitability of CNS neurons and motor …

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

The linear peptide gramicidin forms prototypical ion channels specific for monovalent
cations and has been extensively used to study the organization, dynamics and function of …

KCNQ2 and KCNQ3, both of which are mutated in a type of human neonatal epilepsy, form
heteromeric potassium channels that are expressed in broad regions of the brain. The …