The number of scientific publications on frailty has been increasing exponentially during the
past 15 years (Fig. 1). Studies on the topic are not limited to the geriatric and gerontology …

With ageing, the potency of individual risk factors traditionally associated with common
illnesses declines. Instead, it is becoming clear that the impact of a wide range of age …

Introduction Cognitive impairment is the hallmark of Alzheimer's disease (AD) and related
dementias. However, motor decline has been recently described as a prodromal state that …

Serum vitamin D deficiency is widespread among older adults and is a potential modifiable
risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the …

Objective Cognitive frailty (CF) refers to the co-occurrence of physical frailty (PF) and
cognitive impairment in persons without dementia. We aimed to explore the prevalence and …

Background: Cognitive frailty (CF), defined as the simultaneous presence of cognitive
impairment and physical frailty, is a clinical symptom in early-stage dementia with promise in …

The concept of frailty, now being adopted in most medical disciplines, is attracting growing
interest in neurology. Every day, most neurologists care for patients with varying degrees of …

Mouse models of Alzheimer's disease (AD) exhibit marked differences in life expectancy
depending on their genotype and sex. The assessment of frailty could provide a measure of …

The present study aimed at investigating if the main biomarkers of Alzheimer's disease (AD)
neuropathology and their association with cognitive disturbances and dementia are …

Background Frailty has been associated with cognitive markers of dementia but its
relationship with behavioral markers of dementia are poorly understood. Objectives To …