Epigenetic regulation of gene expression is an increasingly well-understood concept that
explains much of the contribution of an organism's environment and experience to its …

Learning is an essential biological process for survival since it facilitates behavioural
plasticity in response to environmental changes. This process is mediated by a wide variety …

Previous studies demonstrated that a subset of synMuv B mutants ectopically misexpress
germline-specific P-granule proteins in their somatic cells, suggesting a failure to properly …

The significance of noncoding RNAs in animal biology is being increasingly recognized. The
nematode Caenorhabditis elegans has an extensive system of short RNAs that includes …

The retinoblastoma (Rb) tumor suppressor acts with a number of chromatin cofactors in a
wide range of species to suppress cell proliferation. The Caenorhabditis elegans …

The inhibition of transcriptional elongation plays an important role in gene regulation in
metazoans, including C. elegans. Here, we combine genomic and biochemical approaches …

Endogenous small interfering RNAs (endo‐siRNAs) have been discovered in many
organisms, including mammals. In C. elegans, depletion of germline‐enriched endo‐siRNAs …

Small RNA pathways, including the RNA interference (RNAi) pathway and the microRNA
(miRNA) pathway, regulate gene expression, defend against transposable elements and …

RNA interference (RNAi) utilizes small interfering RNAs (siRNAs) to direct silencing of
specific genes through transcriptional and post-transcriptional mechanisms. The siRNA …

Early environmental experiences profoundly influence adult phenotypes through complex
mechanisms that are poorly understood. We previously showed that adult Caenorhabditis …