Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Immuno‐oncology is revolutionizing the treatment of cancers, by inducing the recognition
and elimination of tumor cells by the immune system. Recent advances have focused on …

Summary Long-lived" memory-like" NK cells have been identified in individuals infected by
human cytomegalovirus (HCMV), but little is known about how the memory-like NK cell pool …

The lymphopenia as a major immunological abnormality occurs in the majority of severe
COVID‐19 patients, which is strongly associated with mortality rate. A low proportion of …

Highlights•IFN-I signaling has recently been shown to contribute to viral immune
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple …

Despite widespread influenza vaccination programs, influenza remains a major cause of
morbidity and mortality in older adults. Age-related changes in multiple aspects of the …

Ascorbic acid (AA), also known as vitamin C, was initially identified as the factor preventing
the scurvy disease, and became very popular for its antioxidant properties. It is an important …

L-ascorbic acid (vitamin C) is one of the well-known anti-viral agents, especially to influenza
virus. Since the in vivo anti-viral effect is still controversial, we investigated whether vitamin …

The lungs, a special site that is frequently challenged by tumors, pathogens and other
environmental insults, are populated by large numbers of innate immune cells. Among …

Influenza viruses have perplexed scientists for over a hundred years. Yearly vaccines limit
their spread, but they do not prevent all infections. Therapeutic treatments for those …