Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) with a variety of clinical presentations. The profound heterogeneity of MS is …

Traumatic spinal cord injury (SCI) causes widespread damage to neurons, glia and
endothelia located throughout the spinal parenchyma. In response to the injury, resident and …

Two hallmarks of chronic multiple sclerosis lesions are the absence of significant
spontaneous remyelination and primary as well as secondary neurodegeneration. Both …

While it was long held that T cells were the primary mediators of multiple sclerosis (MS)
pathogenesis, the beneficial effects observed in response to treatment with Rituximab (RTX) …

Most of the current therapies, as well as many of the clinical trials, for multiple sclerosis (MS)
target the inflammatory autoimmune processes, but less than 20% of all clinical trials …

Objective The objective of this paper is to assess, in individuals with clinically stable multiple
sclerosis (MS), the safety, tolerability, pharmacokinetics (PK) and exploratory …

Failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate axons is
thought to be a major cause of the limited ability of the central nervous system to repair …

Introduction: Multiple sclerosis (MS) is the most common inflammatory disease of the central
nervous system (CNS). Demyelination, the main pathology in MS, contributes to clinical …

Background: Immune-mediated demyelination and consequent degeneration of
oligodendrocytes and axons are hallmark features of multiple sclerosis (MS). Remyelination …

Antibodies are vital components of the adaptive immune system for the recognition and
response to foreign antigens. However, some antibodies recognize self-antigens in healthy …