Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility
KK Patel, C Venkatesan, H Abdelhalim, S Zeeshan… - Human genomics, 2023 - Springer
Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular
disease (CVD) deaths in the USA and around the globe. Due to the complex nature …
disease (CVD) deaths in the USA and around the globe. Due to the complex nature …
United Kingdom Biobank (UK Biobank) JACC Focus Seminar 6/8
R Caleyachetty, T Littlejohns, B Lacey, J Bešević… - Journal of the American …, 2021 - jacc.org
An increasing number of people are now living with cardiovascular disease (CVD), with
concomitant CVD-related hospitalizations, operations, and prescriptions. To ultimately …
concomitant CVD-related hospitalizations, operations, and prescriptions. To ultimately …
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
Cardiometabolic diseases are the leading cause of death worldwide. Despite a known
genetic component, our understanding of these diseases remains incomplete. Here, we …
genetic component, our understanding of these diseases remains incomplete. Here, we …
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are
leading causes of sudden death and heart failure in young, otherwise healthy, individuals …
leading causes of sudden death and heart failure in young, otherwise healthy, individuals …
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading
indication for heart transplantation. Many rare genetic variants have been associated with …
indication for heart transplantation. Many rare genetic variants have been associated with …
Genetic drug target validation using Mendelian randomisation
AF Schmidt, C Finan, M Gordillo-Marañón… - Nature …, 2020 - nature.com
Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …
relevance of environmental and biological risk factors for disease. However, causal …
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Heart failure is a leading cause of cardiovascular morbidity and mortality. However, the
contribution of common genetic variation to heart failure risk has not been fully elucidated …
contribution of common genetic variation to heart failure risk has not been fully elucidated …
Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study
S Yuan, P Carter, M Bruzelius, M Vithayathil, S Kar… - …, 2020 - thelancet.com
Background Tumour necrosis factor (TNF) inhibitors are used in the treatment of certain
autoimmune diseases but given the role of TNF in tumour biology and atherosclerosis, such …
autoimmune diseases but given the role of TNF in tumour biology and atherosclerosis, such …