Conspectus The use of quaternary stereocenters during lead candidate optimization
continues to grow because of improved physiochemical and pharmacokinetic profiles of …

Conspectus Transition metal catalyzed cross-electrophile coupling of alkyl electrophiles has
evolved into a privileged strategy that permits the facile construction of valuable C (sp3)–C …

Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are appealing but
limited to specific substrate classes. Here, we report electroreductive XEC of previously …

Metal-catalyzed cross-electrophile couplings have become a valuable tool for carbon–
carbon bond formation. This minireview provides a comprehensive overview of the recent …

As alcohols are ubiquitous throughout chemical science, this functional group represents a
highly attractive starting material for forging new C–C bonds. Here, we demonstrate that the …

Cross-coupling reactions, which were discovered almost 50 years ago, are widely used in
both industry and academia. Even though cross-coupling reactions now represent mature …

Alkene dicarbofunctionalizations enable the streamlined construction of aliphatic structures
and have thus been the subject of intense research efforts. Despite significant progress …

Transformation of sterically hindered tertiary alkyl electrophiles under nickel-catalyzed
conditions to forge C (sp3)–C bonds and simultaneously create challenging all-carbon …

Ni-catalyzed cross-electrophile coupling reactions have emerged as appealing methods to
construct organic molecules without the use of stoichiometric organometallic reagents. The …

Conspectus The implementation of any chemical reaction in a structurally complex setting
(King, SMJ Org. Chem. 2014, 79, 8937) confronts structurally defined barriers: steric …