Activation of PI3K (phosphoinositide 3-kinase) is a shared response to engagement of
diverse types of transmembrane receptors. Depending on the cell type and stimulus, PI3K …

This article recapitulates the evidence on the role of mammalian targets of rapamycin
(mTOR) complex pathways in multiple sclerosis (MS). Key biological processes that intersect …

Summary The PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation
of CD4+ T cells upon stimulation through TCR and CD28. Here, we demonstrate that the …

Curcumin is a natural compound that appears to be promising for clinical application, as it
has been shown in in vitro and in vivo studies to exert antitumor effects by modulating …

In autoimmune disease body's own immune system knows healthy cells as undesired and
foreign cells. Over 80 types of autoimmune diseases have been recognized. Currently, at …

Mitochondria are principal metabolic organelles that are increasingly unveiled as immune
regulators. However, it is currently not known whether mitochondrial-encoded peptides …

Cervical cancer (CC) with early metastasis of the primary tumor results in poor prognosis
and poor therapeutic outcomes. MicroRNAs (miRNAs) are small, noncoding RNA molecules …

It took decades to arrive at the general consensus dismissing the notion that the immune
system is independent of the central nervous system. In the case of uncontrolled systemic …

Abstract The PI3K/AKT/mTOR pathway is an intracellular signalling pathway that regulates
cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests …

Rapamycin inhibits the mechanistic (formally mammalian) target of rapamycin (mTOR), an
evolutionarily conserved intracellular kinase that influences activation of growth signaling …