The value of thoroughly understanding the thermodynamics specific to a drug
discovery/design study is well known. Over the past decade, the crucial roles of water …

Allosteric communication in proteins regulates a plethora of downstream processes in
subcellular signaling pathways. Describing the effects of cooperative ligand binding on the …

Drying can significantly improve the stability of protein drugs compared with liquid
formulation. This chapter discusses mechanisms of protein stabilization in liquid and dried …

Crystal structures of diverse protein kinase catalytic subunits reveal a number of water
molecules whose positions within the protein core are better preserved than amino acid …

Abstract Peptidyl-Prolyl-Bindungen (Xaa-Pro) nehmen eine Sonderstellung innerhalb von
Peptiden und Proteinen ein, da sie im Gegensatz zu nicht-prolinhaltigen Peptidindungen …

The role of intracellular water in biomolecular function is well recognized and yet quantifying
this is challenging. This is largely because protein hydration is extremely sensitive to the …

Enzymes are ubiquitous in biological systems. They catalyze chemical reactions and are
involved in many biochemical processes. The enzyme of interest is Pseudomonas …