Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Background: The vascular complications of diabetes mellitus are the major causes of
morbidity and mortality among people with diabetes. Circular RNAs are a class of …

Chronic exposure of glucose rich environment creates several physiological and
pathophysiological changes. There are several pathways by which hyperglycemia …

Diabetes mellitus (DM) is associated with several microvascular and macrovascular
complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases …

Angiogenesis has traditionally been viewed from the perspective of how endothelial cells
(ECs) coordinate migration and proliferation in response to growth factor activation to form …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

Diabetes mellitus (DM) has become a major public health threat across the globe. Current
antidiabetic therapies are based on synthetic drugs that very often have side effects. It has …

Diabetes is a chronic disease, characterized by hyperglycemia, which refers to the elevated
levels of glucose in the blood, due to the inability of the body to produce or use insulin …