Non-coding RNA regulatory networks

S Panni, RC Lovering, P Porras, S Orchard - Biochimica et biophysica acta …, 2020 - Elsevier
It is well established that the vast majority of human RNA transcripts do not encode for
proteins and that non-coding RNAs regulate cell physiology and shape cellular functions. A …

Mechanisms of Mendelian dominance

RA Veitia, S Caburet, JA Birchler - Clinical Genetics, 2018 - Wiley Online Library
Genetic dominance has long been considered as a qualitative reflection of interallelic
interactions. Dominance arises from many multiple sources whose unifying theme is the …

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

G Bindea, B Mlecnik, H Hackl, P Charoentong… - …, 2009 - academic.oup.com
We have developed ClueGO, an easy to use Cytoscape plug-in that strongly improves
biological interpretation of large lists of genes. ClueGO integrates Gene Ontology (GO) terms …

Integration of biological networks and gene expression data using Cytoscape

MS Cline, M Smoot, E Cerami, A Kuchinsky… - Nature protocols, 2007 - nature.com
Cytoscape is a free software package for visualizing, modeling and analyzing molecular and
genetic interaction networks. This protocol explains how to use Cytoscape to analyze the …

Acetylation site specificities of lysine deacetylase inhibitors in human cells

C Schölz, BT Weinert, SA Wagner, P Beli… - Nature …, 2015 - nature.com
Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being
investigated in clinical trials for treatment of cancer and other diseases. However, their …

A survey of two-dimensional graph layout techniques for information visualisation

H Gibson, J Faith, P Vickers - Information visualization, 2013 - journals.sagepub.com
Many algorithms for graph layout have been devised over the last 30 years spanning both
the graph drawing and information visualisation communities. This article first reviews the …

Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer

B Mlecnik, M Tosolini, P Charoentong, A Kirilovsky… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Colorectal cancer is a complex disease involving immune defense
mechanisms within the tumor. Herein, we used data integration and biomolecular network …

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

S Leidel, PGA Pedrioli, T Bucher, R Brost, M Costanzo… - Nature, 2009 - nature.com
Ubiquitin-like proteins (UBLs) can change protein function, localization or turnover by
covalent attachment to lysine residues. Although UBLs achieve this conjugation through an …

High performance of photosynthesis and osmotic adjustment are associated with salt tolerance ability in rice carrying drought tolerance QTL: physiological and co …

N Nounjan, P Chansongkrow… - Frontiers in plant …, 2018 - frontiersin.org
Understanding specific biological processes involving in salt tolerance mechanisms is
important for improving traits conferring tolerance to salinity, one of the most important …

Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

M Spitzer, E Griffiths, KM Blakely… - Molecular systems …, 2011 - embopress.org
Resistance to widely used fungistatic drugs, particularly to the ergosterol biosynthesis
inhibitor fluconazole, threatens millions of immunocompromised patients susceptible to …