Relaxin family peptides and their receptors

RAD Bathgate, ML Halls… - Physiological …, 2013 - journals.physiology.org
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Membrane receptors: structure and function of the relaxin family peptide receptors

RCK Kong, PJ Shilling, DK Lobb, PR Gooley… - Molecular and cellular …, 2010 - Elsevier
The receptors for members of the relaxin peptide family have only recently been discovered
and are G-protein-coupled receptors (GPCRs). Relaxin and insulin-like peptide 3 (INSL3) …

FTO intronic SNP strongly influences human neck adipocyte browning determined by tissue and PPARγ specific regulation: A transcriptome analysis

BB Tóth, R Arianti, A Shaw, A Vámos, Z Veréb… - Cells, 2020 - mdpi.com
Brown adipocytes, abundant in deep-neck (DN) area in humans, are thermogenic with anti-
obesity potential. FTO pro-obesity rs1421085 T-to-C single-nucleotide polymorphism (SNP) …

The minimal active structure of human relaxin-2

MA Hossain, KJ Rosengren, CS Samuel… - Journal of Biological …, 2011 - ASBMB
H2 relaxin is a peptide hormone associated with a number of therapeutically relevant
physiological effects, including regulation of collagen metabolism and multiple vascular …

The diverse influences of relaxin-like peptide family on tumor progression: Potential opportunities and emerging challenges

J Jung, H Han - Heliyon, 2024 - cell.com
Relaxin-like peptide family exhibit differential expression patterns in various types of cancers
and play a role in cancer development. This family participates in tumorigenic processes …

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

X Lian, S Beer-Hammer, GM König, E Kostenis… - Frontiers in …, 2018 - frontiersin.org
Background: Relaxins are small peptide hormones, which are novel candidate molecules
that play important roles in cardiometablic syndrome. Relaxins are structurally related to the …

The insulin-like factor 3 (INSL3)-receptor (RXFP2) network functions as a germ cell survival/anti-apoptotic factor in boar testes

D Sagata, I Minagawa, H Kohriki, AM Pitia… - …, 2015 - academic.oup.com
Relaxin-like factor, commonly known as insulin-like factor (INSL3), is essential for testis
descent during fetal development; however, its function in the adult testis is still being …

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2

DJ Scott, KJ Rosengren… - Molecular …, 2012 - academic.oup.com
Relaxin and insulin-like peptide 3 (INSL3) are peptide hormones with a number of important
physiological roles in reproduction, regulation of extracellular matrix turnover, and …

Biological role and clinical significance of insulin-like peptide 3

R Ivell, R Anand-Ivell - Current Opinion in Endocrinology …, 2011 - journals.lww.com
The Leydig cell hormone INSL3 is responsible for the first phase of testicular descent during
pregnancy and may have multiple roles as a gender-specific circulating hormone in the …

Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1)

NA Diepenhorst, EJ Petrie, CZ Chen, A Wang… - Journal of Biological …, 2014 - ASBMB
Relaxin, an emerging pharmaceutical treatment for acute heart failure, activates the relaxin
family peptide receptor (RXFP1), which is a class A G-protein-coupled receptor. In addition …