[HTML][HTML] 3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

V Mehta, SN Rath - Bio-Design and Manufacturing, 2021 - Springer
In the last few years, 3D printing has emerged as a promising alternative for the fabrication
of microfluidic devices, overcoming some of the limitations associated with conventional soft …

Emerging tumor-on-chips with electrochemical biosensors

L Lei, B Ma, C Xu, H Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …

Advances in Spheroids and Organoids on a Chip

G Fang, YC Chen, H Lu, D Jin - Advanced Functional Materials, 2023 - Wiley Online Library
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …

Autonomous microlasers for profiling extracellular vesicles from cancer spheroids

Z Wang, G Fang, Z Gao, Y Liao, C Gong, M Kim… - Nano Letters, 2023 - ACS Publications
Self-propelled micro/nanomotors are emergent intelligent sensors for analyzing extracellular
biomarkers in circulating biological fluids. Conventional luminescent motors are often …

Responsive sensors of upconversion nanoparticles

G Lin, D Jin - ACS sensors, 2021 - ACS Publications
Upconversion nanoparticles are a class of luminescent materials that convert longer-
wavelength near-infrared photons into visible and ultraviolet emissions. They can respond to …

[HTML][HTML] Advancements in 3D cell culture systems for personalizing anti-cancer therapies

AMK Law, L Rodriguez de la Fuente, TJ Grundy… - Frontiers in …, 2021 - frontiersin.org
Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …

Mammary tumor organoid culture in non‐adhesive alginate for luminal mechanics and high‐throughput drug screening

G Fang, H Lu, L Rodriguez de la Fuente… - Advanced …, 2021 - Wiley Online Library
Mammary tumor organoids have become a promising in vitro model for drug screening and
personalized medicine. However, the dependency on the basement membrane extract …

A microfluidic multisize spheroid array for multiparametric screening of anticancer drugs and blood–brain barrier transport properties

C Eilenberger, M Rothbauer, F Selinger… - Advanced …, 2021 - Wiley Online Library
Physiological‐relevant in vitro tissue models with their promise of better predictability have
the potential to improve drug screening outcomes in preclinical studies. Despite the …

Analytical and biomedical applications of microfluidics in traditional Chinese medicine research

P Shen, Y Jia, S Shi, J Sun, X Han - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Traditional Chinese medicine (TCM) has significant benefits in the prevention and treatment
of diseases due to its unique theoretical system and research techniques. However, there …

[HTML][HTML] Flipped well-plate hanging-drop technique for growing three-dimensional tumors

Y Jeong, A Tin, J Irudayaraj - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Three-dimensional (3D) tumor culture techniques are gaining popularity as in vitro models of
tumoral tissue analogues. Despite the widespread interest, need, and present-day effort …