Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Benzimidazole-triazole hybrids as antimicrobial and antiviral agents: A systematic review

M Marinescu - Antibiotics, 2023 - mdpi.com
Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …

Design, synthesis, in-vitro and in-silico studies of chromone‐isoxazoline conjugates as anti‐bacterial agents

Y Kanzouai, M Chalkha, H Hadni, M Laghmari… - Journal of Molecular …, 2023 - Elsevier
A novel series of chromone-isoxazoline conjugates was successfully synthesized by the O-
alkylation and 1, 3-dipolar cycloaddition reactions using methyl 7‑hydroxy-4H-chromone-3 …

Calcium carbide: Highly potent solid reagent for the construction of heterocycles

MS Ledovskaya, VV Voronin - Tetrahedron, 2023 - Elsevier
An analysis of the literature over the past 10 years shows that there is a trend towards
simplification of the synthetic procedures, usage of readily available and unexpensive …

Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

MG Salem, SAA El-Ata, EH Elsayed, SN Mali… - RSC …, 2023 - pubs.rsc.org
Breast cancer is a global health concern, with increasing disease burden and disparities in
access to healthcare. Late diagnosis and limited treatment options in underserved areas …

Design, synthesis, theoretical studies, and biological activity evaluation of new nitrogen-containing poly heterocyclic compounds as promising antimicrobial agents

YU Cebeci, ÖÖ Batur, H Boulebd - Journal of Molecular Structure, 2024 - Elsevier
The increasing threat of antibiotic resistance has led to a pressing need for the development
of new antimicrobial agents. Nitrogen-containing heterocycles are widely used in the …

Novel azole–sulfonamide conjugates as potential antimicrobial candidates: synthesis and biological assessment

P Periwal, V Verma, D Kumar, A Kumar… - Future Medicinal …, 2024 - Taylor & Francis
Background: Azole and sulfonamide molecular frameworks are endowed with potent
antimicrobial activity. Materials & methods: A series of azole–sulfonamide conjugates were …

Synthesis of a series of quinoxaline derivatives and their antibacterial effectiveness against pathogenic bacteria

H Khatoon, E Abdul Malek, SM Faudzi… - …, 2024 - Wiley Online Library
The pharmacological importance of quinoxaline derivatives in antibacterial research is well
recognized. This study focuses on the synthesis of new 2, 3‐dichloroquinoxaline derivatives …

Facile one-pot, three-component synthesis and antimicrobial screening of novel hexahydropyrimido [4, 5-b] quinolinediones incorporating phenoxylacetamide core as …

HM Diab, AHM Elwahy, MA Ragheb… - Journal of Molecular …, 2023 - Elsevier
We have investigated in this article the introduction of the phenoxyacetamide moiety, which
has different therapeutic activities, into the biologically important pyrimidoquinoline scaffolds …

Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach

DK Singh, R Kumar - Beilstein Journal of Organic Chemistry, 2023 - beilstein-journals.org
Pyrrole is an important aromatic heterocyclic scaffold found in many natural products and
predominantly used in pharmaceuticals. Continuous efforts are being made to design and …