Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …
Benzimidazole-triazole hybrids as antimicrobial and antiviral agents: A systematic review
M Marinescu - Antibiotics, 2023 - mdpi.com
Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …
due to the special problems they have faced, such as their increasing diversity and …
Design, synthesis, in-vitro and in-silico studies of chromone‐isoxazoline conjugates as anti‐bacterial agents
Y Kanzouai, M Chalkha, H Hadni, M Laghmari… - Journal of Molecular …, 2023 - Elsevier
A novel series of chromone-isoxazoline conjugates was successfully synthesized by the O-
alkylation and 1, 3-dipolar cycloaddition reactions using methyl 7‑hydroxy-4H-chromone-3 …
alkylation and 1, 3-dipolar cycloaddition reactions using methyl 7‑hydroxy-4H-chromone-3 …
Calcium carbide: Highly potent solid reagent for the construction of heterocycles
MS Ledovskaya, VV Voronin - Tetrahedron, 2023 - Elsevier
An analysis of the literature over the past 10 years shows that there is a trend towards
simplification of the synthetic procedures, usage of readily available and unexpensive …
simplification of the synthetic procedures, usage of readily available and unexpensive …
Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity
MG Salem, SAA El-Ata, EH Elsayed, SN Mali… - RSC …, 2023 - pubs.rsc.org
Breast cancer is a global health concern, with increasing disease burden and disparities in
access to healthcare. Late diagnosis and limited treatment options in underserved areas …
access to healthcare. Late diagnosis and limited treatment options in underserved areas …
Design, synthesis, theoretical studies, and biological activity evaluation of new nitrogen-containing poly heterocyclic compounds as promising antimicrobial agents
The increasing threat of antibiotic resistance has led to a pressing need for the development
of new antimicrobial agents. Nitrogen-containing heterocycles are widely used in the …
of new antimicrobial agents. Nitrogen-containing heterocycles are widely used in the …
Novel azole–sulfonamide conjugates as potential antimicrobial candidates: synthesis and biological assessment
P Periwal, V Verma, D Kumar, A Kumar… - Future Medicinal …, 2024 - Taylor & Francis
Background: Azole and sulfonamide molecular frameworks are endowed with potent
antimicrobial activity. Materials & methods: A series of azole–sulfonamide conjugates were …
antimicrobial activity. Materials & methods: A series of azole–sulfonamide conjugates were …
Synthesis of a series of quinoxaline derivatives and their antibacterial effectiveness against pathogenic bacteria
The pharmacological importance of quinoxaline derivatives in antibacterial research is well
recognized. This study focuses on the synthesis of new 2, 3‐dichloroquinoxaline derivatives …
recognized. This study focuses on the synthesis of new 2, 3‐dichloroquinoxaline derivatives …
Facile one-pot, three-component synthesis and antimicrobial screening of novel hexahydropyrimido [4, 5-b] quinolinediones incorporating phenoxylacetamide core as …
We have investigated in this article the introduction of the phenoxyacetamide moiety, which
has different therapeutic activities, into the biologically important pyrimidoquinoline scaffolds …
has different therapeutic activities, into the biologically important pyrimidoquinoline scaffolds …
Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach
Pyrrole is an important aromatic heterocyclic scaffold found in many natural products and
predominantly used in pharmaceuticals. Continuous efforts are being made to design and …
predominantly used in pharmaceuticals. Continuous efforts are being made to design and …