Biological applications of knowledge graph embedding models

SK Mohamed, A Nounu, V Nováček - Briefings in bioinformatics, 2021 - academic.oup.com
Complex biological systems are traditionally modelled as graphs of interconnected
biological entities. These graphs, ie biological knowledge graphs, are then processed using …

On the integration of knowledge graphs into deep learning models for a more comprehensible AI—Three challenges for future research

G Futia, A Vetrò - Information, 2020 - mdpi.com
Deep learning models contributed to reaching unprecedented results in prediction and
classification tasks of Artificial Intelligence (AI) systems. However, alongside this notable …

[HTML][HTML] Clinical evaluation of atlas and deep learning based automatic contouring for lung cancer

T Lustberg, J van Soest, M Gooding… - Radiotherapy and …, 2018 - Elsevier
Background and purpose Contouring of organs at risk (OARs) is an important but time
consuming part of radiotherapy treatment planning. The aim of this study was to investigate …

Discovering protein drug targets using knowledge graph embeddings

SK Mohamed, V Nováček, A Nounu - Bioinformatics, 2020 - academic.oup.com
Motivation Computational approaches for predicting drug–target interactions (DTIs) can
provide valuable insights into the drug mechanism of action. DTI predictions can help to …

Complex query answering with neural link predictors

E Arakelyan, D Daza, P Minervini, M Cochez - arXiv preprint arXiv …, 2020 - arxiv.org
Neural link predictors are immensely useful for identifying missing edges in large scale
Knowledge Graphs. However, it is still not clear how to use these models for answering …

The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species

CJ Mungall, JA McMurry, S Köhler… - Nucleic acids …, 2017 - academic.oup.com
The correlation of phenotypic outcomes with genetic variation and environmental factors is a
core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient …

SMR: medical knowledge graph embedding for safe medicine recommendation

F Gong, M Wang, H Wang, S Wang, M Liu - Big Data Research, 2021 - Elsevier
Most of the existing medicine recommendation systems that are mainly based on electronic
medical records (EMRs) are significantly assisting doctors to make better clinical decisions …

[HTML][HTML] The role of metadata in reproducible computational research

J Leipzig, D Nüst, CT Hoyt, K Ram, J Greenberg - Patterns, 2021 - cell.com
Reproducible computational research (RCR) is the keystone of the scientific method for in
silico analyses, packaging the transformation of raw data to published results. In addition to …

RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine

EC Wood, AK Glen, LG Kvarfordt, F Womack… - BMC …, 2022 - Springer
Background Biomedical translational science is increasingly using computational reasoning
on repositories of structured knowledge (such as UMLS, SemMedDB, ChEMBL, Reactome …

OpenBioLink: a benchmarking framework for large-scale biomedical link prediction

A Breit, S Ott, A Agibetov, M Samwald - Bioinformatics, 2020 - academic.oup.com
Recently, novel machine-learning algorithms have shown potential for predicting
undiscovered links in biomedical knowledge networks. However, dedicated benchmarks for …