NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic,
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …

Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene
products, reverse the modification of proteins by a single ubiquitin (-like) protein, and …

The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the
number of proteins predicted by DNA coding capacities owing to directed posttranslational …

Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies …

The small ubiquitin-like modifier (SUMO) is covalently linked to a variety of proteins and is
deconjugated by SUMO-specific proteases. A characteristic of SUMO modification is that the …

▪ Abstract Small ubiquitin-related modifier (SUMO) family proteins function by becoming
covalently attached to other proteins as post-translational modifications. SUMO modifies …

Attachment of ubiquitin to proteins is a crucial step in many cellular regulatory mechanisms
and contributes to numerous biological processes, including embryonic development, the …

Active-site directed probes are powerful in studies of enzymatic function. We report an active-
site directed probe based on a warhead so far considered unreactive. By replacing the C …

SUMOs (small ubiquitin-like modifiers) are ubiquitin-related proteins that become covalently
conjugated to cellular target proteins that are involved in a variety of processes. Frequently …