Diffuse intrinsic pontine gliomas constitute~ 60–75% of tumors found within the pediatric
brainstem. These malignant lesions present with rapidly progressive symptoms such as …

Drug design is built on the concept that key molecular targets of disease are isolated in the
diseased tissue. Systemic drug administration would be sufficient for targeting in such a …

Convection-enhanced delivery (CED) for the treatment of malignant gliomas is a technique
that can deliver chemotherapeutic agents directly into the tumor and the surrounding …

In spite of aggressive multi-modality treatments, patients diagnosed with anaplastic
astrocytoma and glioblastoma continue to display poor median survival. The success of our …

The purpose of this study was to further evaluate the therapeutic efficacy of convection
enhanced delivery (CED) of carboplatin in combination with radiotherapy for treatment of the …

This 13-year-old boy with a history of cranial irradiation for the CNS recurrence of acute
lymphocytic leukemia developed a glioblastoma in the right cerebellum. Resection and …

The advent of interstitial chemotherapy has significantly increased therapeutic options for
patients with malignant glioma. Interstitial chemotherapy can deliver high concentrations of …

Abstract Brainstem gliomas comprise 10–20% of all pediatric central nervous system (CNS)
tumors and diffuse intrinsic pontine gliomas (DIPGs) account for the majority of these …

Thanks to the recent advances in the development of chemotherapeutics, the morbidity and
mortality of many cancers has decreased significantly. However, compared to oncology in …

Objective Diffuse intrinsic brainstem gliomas are considered to be inoperable. We report our
initial experience of temozolomide (TMZ) administration into brainstem by intracerebral (ic) …