Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Immunotherapy has revolutionized cancer treatment and substantially improved patient
outcome with regard to multiple tumour types. However, most patients still do not benefit …

Purpose: Cisplatin is increasingly used in chemoimmunotherapy and may enhance the T
cell–dependent radiation-induced abscopal effect, but how it promotes antitumor immunity is …

Vitamin A (VA, retinol) and its metabolites (commonly called retinoids) are required for the
proper development of the kidney during embryogenesis, but retinoids also play key roles in …

All-trans retinoic acid is a morphogen during embryogenesis and a teratogen. Cancer is an
error of development, and the retinoic acid receptors (RAR) for all-trans retinoic acid play a …

Immunogenic cell death (ICD) has been a revolutionary modality in cancer treatment since it
kills primary tumors and prevents recurrent malignancy simultaneously. ICD represents a …

Doxorubicin is a potent anticancer drug used to treat a variety of cancer types. However, its
use is limited by doxorubicin-induced cardiotoxicity (DIC). A missense variant in the RARG …

Abstract Bcl-2 phosphorylation at serine-70 (S70pBcl2) confers resistance against drug-
induced apoptosis. Nevertheless, its specific mechanism in driving drug-resistance remains …

Regulated necrosis, also termed necroptosis, is another programmed cell death depending
on a unique molecular pathway that does not overlap with apoptosis. Tumor necrosis factor …

Cisplatin (cis-dichloro-diammine platinum, CDDP) is a well-known chemotherapeutic drug
against a broad spectrum of human malignancies. However, the clinical utility of this …