Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

The most widely used approach for defining gene function is to reduce or completely disrupt
its normal expression. For over a decade, RNAi has ruled the lab, offering a magic bullet to …

Motivation Deciphering the language of non-coding DNA is one of the fundamental
problems in genome research. Gene regulatory code is highly complex due to the existence …

Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Alternative usage of transcript isoforms from the same gene has been hypothesized as an
important feature in cancers. However, differential usage of gene transcripts between …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

Spatial restriction of mRNA to distinct subcellular locations enables local regulation and
synthesis of proteins. However, the organizing principles of mRNA localization remain …

A fully mature mRNA is usually associated to a reference open reading frame encoding a
single protein. Yet, mature mRNAs contain unconventional alternative open reading frames …