The endocrinology of the aging male is complex, with multiple hormones along the
hypothalamic-pituitary-testicular (HPT) axis interacting with one another in feedback. As men …

The somatic Sertoli cell plays an essential role in embryonic determination of male somatic
sex and in spermatogenesis during adult life. One individual Sertoli cell supplies a clone of …

This chapter discusses the modulatory influences regulating the timing of puberty in rats.
The developmental process that leads to puberty in the female rat is based on an …

A wide spectrum of data in the literature shows the relevance of cytokines as paracrine
regulators of spermatogenesis and steroidogenesis in the normal testis. In this brief review …

Obesity in men, particularly when central, is associated with lower total testosterone [TT],
free testosterone [FT] and sex hormone-binding globulin [SHBG], and a greater decline in TT …

To achieve and maintain fertility, the adult mammalian testis produces many generations of
sperm. While testicular integrity is established in the fetus and develops further in juvenile …

Testicular growth during puberty is rapid, and mostly due to germ cell expansion and growth
in seminiferous tubule diameter triggered by androgens. Pre-treatment with FSH before the …

Activin A belongs to the TGF-β superfamily and plays an important role in bone metabolism.
It was reported that a soluble form of extracellular domain of the activin receptor type IIA …

The present study examined the effects in mice of exposure to di (2-ethyl-hexyl) phthalate
(DEHP) throughout pregnancy and lactation on the development and function of the pituitary …

New data have challenged the convention that the adult Sertoli cell population is fixed and
unmodifiable. The Sertoli cell has two distinct functions: 1) formation of the seminiferous …