Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches
R Diehl, F Ferrara, C Müller, AY Dreyer… - Cellular & Molecular …, 2017 - nature.com
Almost every experimental treatment strategy using non-autologous cell, tissue or organ
transplantation is tested in small and large animal models before clinical translation …
transplantation is tested in small and large animal models before clinical translation …
The antagonist of the JAK-1/STAT-1 signaling pathway improves the severity of cerulein-stimulated pancreatic injury via inhibition of NF-κB activity
P Chen, L Huang, Y Zhang… - International …, 2011 - spandidos-publications.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway is widely involved in cell migration, apoptosis and inflammation. However, its exact …
pathway is widely involved in cell migration, apoptosis and inflammation. However, its exact …
Acquisition of humoral transplantation tolerance upon de novo emergence of B lymphocytes
RF Parsons, K Vivek, SY Rostami… - The Journal of …, 2011 - journals.aai.org
A major obstacle to transplantation tolerance is humoral immunity. In this paper, we
demonstrate that the intrinsic developmental propensity of the B lymphocyte compartment for …
demonstrate that the intrinsic developmental propensity of the B lymphocyte compartment for …
Pretreatment of transfused donor splenocytes and allografts with mitomycin C attenuates acute rejection in heart transplantation in mice
Objective The aim of this study was to investigate the effect of pretreatment of donor
splenocytes and grafts with mitomycin C (MMC) on heart allograft survival, as well as to …
splenocytes and grafts with mitomycin C (MMC) on heart allograft survival, as well as to …
Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells
S Zhang, H Dai, N Wan, Y Moore, Z Dai - Plos one, 2010 - journals.plos.org
Background Major histocompatibility complex (MHC) antigens are important for alloimmune
responses as well as immune tolerance. Previous studies have shown that presentation of …
responses as well as immune tolerance. Previous studies have shown that presentation of …
Triazolopyrimidine derivative NK026680 and donor-specific transfusion induces CD4+ CD25+ Foxp3+ T cells and ameliorates allograft rejection in an antigen-specific …
S Emoto, S Shibasaki, A Nagatsu, R Goto, H Ono… - Transplant …, 2021 - Elsevier
We have previously demonstrated the unique properties of a new triazolopyrimidine
derivative, NK026680, which exerts immunosuppressive effects in rat heart transplant model …
derivative, NK026680, which exerts immunosuppressive effects in rat heart transplant model …