Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

Protein arginine methyltransferase (PRMT)-mediated arginine methylation is an important
post-transcriptional modification that regulates various cellular processes including …

The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …

Introduction Intronic repeat expansions in the C9orf72 gene are the most frequent known
single genetic causes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …

PRMT1 plays a vital role in breast tumorigenesis; however, the underlying molecular
mechanisms remain incompletely understood. Herein, we show that PRMT1 plays a critical …

Arginine methylation is a ubiquitous and relatively stable post-translational modification
(PTM) that occurs in three types: monomethylarginine (MMA), asymmetric dimethylarginine …

Protein arginine methyltransferase 1 (PRMT1) is a major type I arginine methyltransferase
that catalyzes the formation of monomethyl and asymmetric dimethylarginine in protein …

Abstract Protein Arginine Methyltransferases (PRMTs) are a family of enzymes regulating
protein arginine methylation, which is a post-translational modification crucial for various …

The methionine addiction of cancer cells is known as the Hoffman effect. While non-cancer
cells in culture can utilize homocysteine in place of methionine for cellular growth, most …

Maintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic
fidelity. Though histone arginine methylation has been shown to play important roles in …