Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications

MM Gerrits, AHM van Vliet, EJ Kuipers… - The Lancet infectious …, 2006 - thelancet.com
Helicobacter pylori is an important human pathogen that colonises the stomach of about half
of the world's population. The bacterium has now been accepted as the causative agent of …

Eradication therapy for Helicobacter pylori

N Vakil, F Megraud - Gastroenterology, 2007 - Elsevier
Eradication therapy for Helicobacter pylori is recommended in a number of clinical
conditions. In this article, we discuss the epidemiology and cellular mechanisms that result …

An update on derivatisation and repurposing of clinical nitrofuran drugs

NH Zuma, J Aucamp, DND David - European Journal of Pharmaceutical …, 2019 - Elsevier
nitrofurans (NFs) have been in clinical use for over 60 years. These affordable drugs are
used for the treatment of a broad spectrum of diseases ranging from urinary tract infections …

Molecular Mechanisms of Antibiotic Resistance and Novel Treatment Strategies for Helicobacter pylori Infections

M Srisuphanunt, P Wilairatana, N Kooltheat… - Tropical Medicine and …, 2023 - mdpi.com
Helicobacter pylori infects approximately 50% of the world's population and is considered
the major etiological agent of severe gastric diseases, such as peptic ulcers and gastric …

Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori

G Sisson, A Goodwin, A Raudonikiene… - Antimicrobial agents …, 2002 - Am Soc Microbiol
Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills
Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species …

Resistance mechanisms of Helicobacter pylori and its dual target precise therapy

Y Gong, Y Yuan - Critical reviews in microbiology, 2018 - Taylor & Francis
Helicobacter pylori drug resistance presents a significant challenge to the successful
eradication of this pathogen. To find strategies to improve the eradication efficacy of H …

[HTML][HTML] “Rescue” regimens after Helicobacter pylori treatment failure

JP Gisbert - World journal of gastroenterology: WJG, 2008 - ncbi.nlm.nih.gov
Helicobacter pylori (H pylori) infection is the main cause of gastritis, gastroduodenal ulcer
disease, and gastric cancer. After more than 20 years of experience in H pylori treatment, in …

Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia …

JEJ Nixon, A Wang, J Field, HG Morrison… - Eukaryotic …, 2002 - Am Soc Microbiol
Giardia lamblia and Entamoeba histolytica are amitochondriate, microaerophilic protists
which use fermentation enzymes like those of bacteria to survive anaerobic conditions within …

A Prospective, Randomized Study of Quadruple Therapy and High‐Dose Dual Therapy for Treatment of Helicobacter Pylori Resistant to Both Metronidazole and …

S Miehlke, C Kirsch, W Schneider‐Brachert… - …, 2003 - Wiley Online Library
ABSTRACT Background and Aim. Failure of primary anti‐H. pylori therapy results in a high
rate of antimicrobial resistance. Here, we investigated the efficacy of high‐dose dual therapy …

Prevalence and evolution of Helicobacter pylori resistance to 6 antibacterial agents over 12 years and correlation between susceptibility testing methods

L Boyanova, G Gergova, R Nikolov, L Davidkov… - … and infectious disease, 2008 - Elsevier
The aim of this study was to evaluate Helicobacter pylori antibacterial resistance in 2005 to
2007, resistance evolution since 1996 to 1999, and performance of breakpoint susceptibility …