The pulmonary route has long been used for drug administration for both local and systemic
treatment. It possesses several advantages, which can be categorized into physiological, ie …

There is progressive evolution in the use of inhalable drug delivery systems (DDSs) for lung
cancer therapy. The inhalation route offers many advantages, being non-invasive method of …

During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Local administration of therapeutics by inhalation for treatment of lung diseases has the
ability to deliver drugs, nucleic acids and peptides specifically to the site of their action and …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Since recurrence and metastasis of pancreatic cancer has a worse prognosis,
chemotherapy has been typically performed to attack the remained malignant cells after …

Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4
MPa and 31.1° C. Given the request for consumption of a green solvent for the environment …

Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …

Considering the challenges associated with conventional chemotherapy, targeted and local
delivery of chemotherapeutics via nanoparticle (NP) carriers to the lungs is an emerging …

The solubility and bioavailability of pharmaceutical compounds are increased via size
reduction. The conventional size reduction methods have some disadvantages. The …