Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

Cancer is often considered a genetic disease. However, much of the enormous plasticity of
cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and …

The ability to quantify cellular heterogeneity is a major advantage of single-cell
technologies. However, statistical methods often treat cellular heterogeneity as a nuisance …

Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family,
play a vital role in the control of cell migration. Using predictive mathematical modeling …

With the advent of single-cell RNA-sequencing (scRNA-seq), it is possible to measure the
expression dynamics of genes at the single-cell level. Through scRNA-seq, a huge amount …

The standard analysis pipeline for single-cell RNA-seq data consists of sequential steps
initiated by clustering the cells. An innate limitation of this pipeline is that an imperfect …

Although in vivo extracellular microenvironments are dynamic, most in vitro studies are
conducted under static conditions. Here, we exposed diffuse large B-cell lymphoma …

Single-cell measurements routinely demonstrate high levels of variation between cells, but
fewer studies provide insight into the analytical and biological sources of this variation. This …

Even today two bacterial lung infections, namely pneumonia and tuberculosis, are among
the 10 most frequent causes of death worldwide. These infections still lack effective …

Biochemical networks are dynamic and multi-dimensional systems, consisting of tens or
hundreds of molecular components. Diseases such as cancer commonly arise due to …