Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …

The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

Injury is a key driver of inflammation, a critical yet necessary response involving several
mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous …

Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

Background Multiple pathophysiological processes have been described in Alzheimer's
disease (AD). Their inter-individual variations, complex interrelations, and relevance for …

Inflammatory protein biomarkers induced by immune responses have been associated with
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …

Innate immune activation is a major contributor to Alzheimer's Disease (AD)
pathophysiology, although the mechanisms involved are poorly understood. Chemokine CC …

Our recent study has established that young blood factors are not causal, nor necessary, for
the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral …

Previous animal and human studies suggest potential links between maternal exposure to
per-and polyfluoroalkyl substances (PFASs) and adverse birth outcomes. As spontaneous …