Determining sexual fate is an integral part of reproduction, used as a means to enrich the
genome. A variety of such regulatory mechanisms have been described so far and some of …

Sex determination is a complicated process involving large-scale modifications in gene
expression affecting virtually every tissue in the body. Although the evolutionary origin of sex …

Background Sex-determining systems have evolved independently in vertebrates. Placental
mammals and marsupials have an XY system, birds have a ZW system. Reptiles and …

Background Recent studies in pigs have detected copy number variants (CNVs) using the
Comparative Genomic Hybridization technique in arrays designed to cover specific porcine …

In Xenopus laevis, β-catenin-mediated dorsal axis formation can be suppressed by
overexpression of the HMG-box transcription factor XSOX3. Mutational analysis indicates …

Abstract In eutherian ('placental'mammals, sex is determined by the presence or absence of
the Y chromosome-borne gene SRY, which triggers testis determination. Marsupials also …

SOX14 is a member of the SOXB2 subgroup of transcription factors implicated in neural
development. Although the first SOX14 gene in vertebrates was cloned and characterized …

Background How nervous systems evolved remains an unresolved question. Previous
studies in vertebrates and arthropods revealed that homologous genes regulate important …

In higher vertebrates, the expression of Sox2, a group B1 Sox gene, is the hallmark of neural
primordial cell state during the developmental processes from embryo to adult. Sox2 is …

Background Sox domain containing genes are important metazoan transcriptional
regulators implicated in a wide rage of developmental processes. The vertebrate B …