Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

The emergence and convergence of cancer genomics, targeted therapies, and network
oncology have significantly expanded the landscape of protein–protein interaction (PPI) …

Proteasome-mediated degradation is a common mechanism by which cells renew their
intracellular proteins and maintain protein homeostasis. In this process, the E3 ubiquitin …

MDM2 and MDMX function as key regulators of p53 by binding to its N terminus, inhibiting its
transcriptional activity, and promoting degradation. MDM2 and MDMX overexpression or …

The tumor suppressor p53 plays a central role in anti-tumorigenesis and cancer therapy. It
has been described as “the guardian of the genome”, because it is essential for conserving …

The growth inhibitory activity of p53 tumor suppressor is tightly regulated by interaction with
two negative regulatory proteins, murine double minute 2 (MDM2) and X (MDMX), which are …

p53 is a transcription factor that activates the expression of a set of genes that serve as a
critical barrier to oncogenesis. Inactivation of p53 is the most common characteristic in …

Three new thiosemicarbazones (TSCs) HL 1–HL 3 as triapine analogues bearing a redox-
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …

Increasing knowledge of the relationship between p53 and MDM2 has led to development of
potential small molecule inhibitors useful for clinical studies. Herein, we discuss the …

Controlled production of cyclin dependent kinases (CDK) and stabilization of tumor
suppressor genes are the most important factors involved in preventing carcinogenesis. The …