Designs of continuous-flow pharmaceutical crystallizers: developments and practice

M Jiang, RD Braatz - CrystEngComm, 2019 - pubs.rsc.org
Crystallization is an effective, low-cost purification & formulation process widely applied to
pharmaceuticals and fine chemicals. This review describes recent advances in research on …

Recent progress of continuous crystallization

T Wang, H Lu, J Wang, Y Xiao, Y Zhou, Y Bao… - Journal of industrial and …, 2017 - Elsevier
Continuous crystallization has always been a hot topic in industrial crystallization. Many
efforts have been made to improve the continuous crystallization, either by designing novel …

Mechanisms and control of impurities in continuous crystallization: a review

C Darmali, S Mansouri, N Yazdanpanah… - Industrial & …, 2018 - ACS Publications
Crystallization has been applied to a broad range of industries such as bulk and fine
chemicals and the pharmaceutical and food industries. It is important to strategically control …

Semi-continuous and continuous processes for enantiomeric separation

M Ciriani, R Oliveira, CAM Afonso - Green Chemistry, 2022 - pubs.rsc.org
Chiral resolution is an operation of great interest and increasing importance for the scientific
community and industry. There are two approaches to provide enantiomerically pure …

Enantiomer-selective magnetization of conglomerates for quantitative chiral separation

X Ye, J Cui, B Li, N Li, R Wang, Z Yan, J Tan… - Nature …, 2019 - nature.com
Selective crystallization represents one of the most economical and convenient methods to
provide large-scale optically pure chiral compounds. Although significant development has …

Crystallization in fluidized bed reactors: from fundamental knowledge to full-scale applications

MM Seckler - Crystals, 2022 - mdpi.com
A review is presented on fifty years of research on crystallization in fluidized bed reactors
(FBRs). FBRs are suitable for recovery of slightly soluble compounds from aqueous …

[HTML][HTML] Applications of ultrasound to chiral crystallization, resolution and deracemization

C Xiouras, A Fytopoulos, J Jordens… - Ultrasonics …, 2018 - Elsevier
Industrial synthesis of enantiopure compounds is nowadays heavily based on the
separation of racemates through crystallization processes. Although the application of …

[HTML][HTML] Shortcut model to evaluate the performance of continuous preferential crystallization for conglomerates forming chiral systems

S Bhandari, H Lorenz, A Seidel-Morgenstern - Chemical Engineering …, 2024 - Elsevier
The separation of two enantiomers of a chiral molecule is one of the most difficult tasks for
separation technology. Among the available methods, Preferential Crystallization (PC) offers …

Temperature Cycling Induced Deracemization of dl-Asparagine Monohydrate with Immobilized Amino Acid Racemase

K Intaraboonrod, I Harriehausen, T Carneiro… - Crystal Growth & …, 2020 - ACS Publications
Temperature cycling induced deracemization (TCID) is an attractive method to provide a
pure enantiomer from a racemic solid phase. In this work, we performed deracemization of …

Model-based analysis of continuous crystallization/reaction processes separating conglomerate forming enantiomers

T Köllges, T Vetter - Crystal Growth & Design, 2017 - ACS Publications
The separation of conglomerate forming chiral molecules is investigated in continuous
processes combining crystallization, milling, and a racemization reaction in solution. Two …