Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …

This paper presents an overview of methods that have been proposed for the analysis of
breast cancer histopathology images. This research area has become particularly relevant …

Advances in the quality of whole-slide images have set the stage for the clinical use of digital
images in anatomic pathology. Along with advances in computer image analysis, this raises …

In anatomic pathology, immunohistochemistry (IHC) serves as a diagnostic and prognostic
method for identification of disease markers in tissue samples that directly influences …

Pathological evaluation of tumor tissue is pivotal for diagnosis in cancer patients and
automated image analysis approaches have great potential to increase precision of …

Background Breast cancer management depends on biomarkers including estrogen
receptor, progesterone receptor, and human epidermal growth factor receptor 2 …

Breast cancer is the most common malignant disease in women worldwide. In recent
decades, earlier diagnosis and better adjuvant therapy have substantially improved patient …

Abstract Immunohistochemical (IHC) assays performed on formalin-fixed paraffin-embedded
(FFPE) tissue sections traditionally have been semi-quantified by pathologist visual scoring …

Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral
part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer …

Tissue biomarker scoring by pathologists is central to defining the appropriate therapy for
patients with cancer. Yet, inter-pathologist variability in the interpretation of ambiguous …