To maintain the homeostatic environment required for proper function of central nervous
system (CNS) neurons the endothelial cells of CNS microvessels tightly regulate the …

Vedolizumab is a novel therapeutic monoclonal antibody recently approved for the treatment
of moderately to severely active ulcerative colitis and Crohn's disease in adults who have …

Background Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute
effective treatment for ulcerative colitis. Methods We conducted two integrated randomized …

Background & Aims There is an increasing need for new treatments for patients with Crohn's
disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has …

Background & Aims The efficacy and safety of vedolizumab, a humanized immunoglobulin
G1 monoclonal antibody against the integrin α4β7, were demonstrated in multicenter, phase …

Background Vedolizumab is a gut-selective α4β7 integrin antagonist for the treatment of
moderately to severely active Crohn's disease (CD). Aims of this study were to characterize …

Vedolizumab is a humanized anti-α 4 β 7 integrin monoclonal antibody that selectively
blocks trafficking of memory T cells to inflamed gut tissue by inhibiting the α 4 β 7-mucosal …

Inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC), and Crohn's
disease (CD), are a group of disorders characterized by chronic, relapsing, and remitting, or …

Regulation of vascular permeability, recruitment of leukocytes from blood to tissue and
angiogenesis are all processes that occur at the level of the microvasculature during both …

Inflammatory bowel disease (IBD) is a group of chronic disorders of the gastrointestinal tract
comprising Crohn's disease (CD) and ulcerative colitis (UC). Their etiologies are unknown …