Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

D Lebeaux, A Chauhan, O Rendueles, C Beloin - Pathogens, 2013 - mdpi.com
The influence of microorganisms growing as sessile communities in a large number of
human infections has been extensively studied and recognized for 30–40 years, therefore …

Two-component systems required for virulence in Pseudomonas aeruginosa

VI Francis, EC Stevenson, SL Porter - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

The roles of extracellular DNA in the structural integrity of extracellular polymeric substance and bacterial biofilm development

T Das, S Sehar, M Manefield - Environmental microbiology …, 2013 - Wiley Online Library
Bacteria adhere to natural and engineered surfaces and develop into mature biofilms
encased in self‐produced extracellular polymeric substances (EPSs). EPS consists of …

Two component regulatory systems and antibiotic resistance in Gram-negative pathogens

AY Bhagirath, Y Li, R Patidar, K Yerex, X Ma… - International journal of …, 2019 - mdpi.com
Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …

Catheter-associated urinary tract infection by Pseudomonas aeruginosa is mediated by exopolysaccharide-independent biofilms

SJ Cole, AR Records, MW Orr, SB Linden… - Infection and …, 2014 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic human pathogen that is especially adept at
forming surface-associated biofilms. P. aeruginosa causes catheter-associated urinary tract …

Promise for plant pest control: root-associated pseudomonads with insecticidal activities

P Kupferschmied, M Maurhofer, C Keel - Frontiers in plant science, 2013 - frontiersin.org
Insects are an important and probably the most challenging pest to control in agriculture, in
particular when they feed on belowground parts of plants. The application of synthetic …

Antimicrobial resistance: two-component regulatory systems and multidrug efflux pumps

GV De Gaetano, G Lentini, A Famà, F Coppolino… - Antibiotics, 2023 - mdpi.com
The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the
various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps …

Extracytoplasmic function sigma factors in Pseudomonas aeruginosa

S Chevalier, E Bouffartigues, A Bazire… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The opportunistic pathogen Pseudomonas aeruginosa, like all members of the genus
Pseudomonas, has the capacity to thrive in very different environments, ranging from water …