Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor
Creatine kinases (CKs) provide local ATP production in periods of elevated energetic
demand, such as during rapid anabolism and growth. Thus, creatine energetics has …
demand, such as during rapid anabolism and growth. Thus, creatine energetics has …
Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism
CT Supuran - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
While the carbonic anhydrase (CA, EC 4.2. 1.1) superfamily of enzymes has been described
primarily as involved only in pH regulation for decades, it also has many other important …
primarily as involved only in pH regulation for decades, it also has many other important …
Shaping the immune landscape: Multidimensional environmental stimuli refine macrophage polarization and foster revolutionary approaches in tissue regeneration
JD Xue, J Gao, AF Tang, C Feng - Heliyon, 2024 - cell.com
In immunology, the role of macrophages extends far beyond their traditional classification as
mere phagocytes; they emerge as pivotal architects of the immune response, with their …
mere phagocytes; they emerge as pivotal architects of the immune response, with their …
Extracellular vesicles released by cancer-associated fibroblast-induced myeloid-derived suppressor cells inhibit T-cell function
Myeloid cells are known to play a crucial role in creating a tumor-promoting and immune
suppressive microenvironment. Our previous study demonstrated that primary human …
suppressive microenvironment. Our previous study demonstrated that primary human …
Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes
DE Phelan, C Mota, MJ Strowitzki… - … and Cell Biology, 2023 - Wiley Online Library
CO2 is produced during aerobic respiration. Normally, levels of CO2 in the blood are tightly
regulated but pCO2 can rise (hypercapnia, pCO2> 45 mmHg) in patients with lung diseases …
regulated but pCO2 can rise (hypercapnia, pCO2> 45 mmHg) in patients with lung diseases …
CRISPR-Cas9-mediated deletion of carbonic anhydrase 2 in the ciliary body to treat glaucoma
J Jiang, K Kong, X Fang, D Wang, Y Zhang, P Wang… - Cell Reports …, 2024 - cell.com
Summary The carbonic anhydrase 2 (Car2) gene encodes the primary isoenzyme
responsible for aqueous humor (AH) production and plays a major role in the regulation of …
responsible for aqueous humor (AH) production and plays a major role in the regulation of …
Analysis of Free Circulating Messenger Ribonucleic Acids in Serum Samples from Late-Onset Spinal Muscular Atrophy Patients Using nCounter NanoString …
M Leo, LI Schmitt, F Mairinger, A Roos, C Hansmann… - Cells, 2023 - mdpi.com
5q-related Spinal muscular atrophy (SMA) is a hereditary multi-systemic disorder leading to
progressive muscle atrophy and weakness caused by the degeneration of spinal motor …
progressive muscle atrophy and weakness caused by the degeneration of spinal motor …
Intraoperative end-tidal carbon dioxide levels are not associated with recurrence-free survival after elective pancreatic cancer surgery: a retrospective cohort study
S Dehne, L Kirschner, R Klotz, S Kilian… - Frontiers in …, 2024 - frontiersin.org
Background Intraoperative end-tidal carbon dioxide concentrations (EtCO2) values are
associated with recurrence-free survival after colorectal cancer surgery. However, it is …
associated with recurrence-free survival after colorectal cancer surgery. However, it is …
[HTML][HTML] Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery
S Dehne, L Kirschner, MJ Strowitzki, S Kilian… - Journal of Clinical …, 2024 - Elsevier
Study objective Higher levels of carbon dioxide (CO 2) increase the invasive abilities of
colon cancer cells in vitro. Studies assessing target values for end-tidal CO 2 concentrations …
colon cancer cells in vitro. Studies assessing target values for end-tidal CO 2 concentrations …
Laparoscopic-Assisted Colorectal Resection Can Reduce the Inhibition of Immune Function Compared with Conventional Open Surgery: A Retrospective Clinical …
B Shi, Q Tai, J Chen, X Shi, G Chen, H Yao… - Journal of Clinical …, 2023 - mdpi.com
Background: Immune function is an important indicator for assessing postoperative recovery
and long-term survival in patients with malignancy, and laparoscopic surgery is thought to …
and long-term survival in patients with malignancy, and laparoscopic surgery is thought to …