Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Non-covalent complexes of glycolytic enzymes, called metabolons, were postulated in the
1970s, but the concept has been controversial. Here we show that a c-Myc-responsive long …

Long non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology,
contributing to tumor proliferation, invasion, and metastasis. Here, we describe a role for the …

The abnormal upregulation of programmed death ligand-1 (PD-L1) on tumor cells impedes
T-cell mediated cytotoxicity through PD-1 engagement, and further exploring the …

Protein ubiquitination is an important mechanism for regulating the activity and levels of
proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to …

The ubiquitin–proteasome system (UPS) has emerged as a therapeutic focus and target for
the treatment of cancer. The most clinically successful UPS-active agents (bortezomib and …

The aim of the present study was to perform a systematic review of published studies to
provide a robust estimation of the use of procalcitonin (ProCT) as a diagnostic marker of …

Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major
cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing …

The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation
and turnover, of many proteins vital to cellular regulation and function. The UPS comprises a …