Experimental kinetics of non‐native protein aggregation are of practical importance in that
they help dictate viable processing, formulation, and storage conditions for biotechnology …

Bacterial inclusion bodies (IBs) are functional, non-toxic amyloids occurring in recombinant
bacteria showing analogies with secretory granules of the mammalian endocrine system …

A mathematical model is presented of the kinetics of non-native protein aggregation that
combines Lumry− Eyring and nucleated polymerization (LENP) descriptions. The LENP …

In recent years, phenotypic-based screens have become increasingly popular in drug
discovery. A major challenge of this approach is that it does not provide information about …

In this review the mechanisms of protein folding, misfolding, and aggregation as well as the
mechanisms of cell defense against toxic protein aggregates are considered. Misfolded and …

Rapid identification of small molecules that interact with protein targets using a generic
screening method greatly facilitates the development of therapeutic agents. The authors …

Current studies on materials that exhibit metamaterial properties are mainly focused on
lithography-generated 2D substrates. Here we report the successful fabrication of 22 nm …

The aggregation of insulin is complicated by the coexistence of various multimers, especially
in the presence of Zn2+. Most investigations of insulin multimerization tend to overlook …

The overall conformational stability of a model IgG2 monoclonal antibody (mAb) was
examined as a function of temperature and pH using an empirical phase diagram approach …

Chemical chaperones including arginine and its derivatives are widely used by biochemists
working on the design of agents, which are able to efficiently suppress protein aggregation …