[HTML][HTML] Recent advances in sensing the inter-biomolecular interactions at the nanoscale–A comprehensive review of AFM-based force spectroscopy

A Lostao, KS Lim, MC Pallarés, A Ptak… - International journal of …, 2023 - Elsevier
Biomolecular interactions underpin most processes inside the cell. Hence, a precise and
quantitative understanding of molecular association and dissociation events is crucial, not …

Glycosylated gold nanoparticles in point of care diagnostics: From aggregation to lateral flow

AN Baker, GW Hawker-Bond, PG Georgiou… - Chemical Society …, 2022 - pubs.rsc.org
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …

The SARS-COV-2 spike protein binds sialic acids and enables rapid detection in a lateral flow point of care diagnostic device

AN Baker, SJ Richards, CS Guy, TR Congdon… - ACS central …, 2020 - ACS Publications
There is an urgent need to understand the behavior of the novel coronavirus (SARS-COV-2),
which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a …

Automation and data-driven design of polymer therapeutics

R Upadhya, S Kosuri, M Tamasi, TA Meyer… - Advanced drug delivery …, 2021 - Elsevier
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …

Plasmonic detection of SARS-CoV-2 spike protein with polymer-stabilized glycosylated gold nanorods

PG Georgiou, CS Guy, M Hasan, A Ahmad… - ACS Macro …, 2022 - ACS Publications
The COVID-19 pandemic has highlighted the need for innovative biosensing, diagnostic,
and surveillance platforms. Here we report that glycosylated, polymer-stabilized, gold …

State-of-the-Art of Nanodiagnostics and Nanotherapeutics against SARS-CoV-2

MA Derakhshan, A Amani… - ACS applied materials & …, 2021 - ACS Publications
The pandemic outbreak of SARS-CoV-2, with millions of infected patients worldwide, has
severely challenged all aspects of public health. In this regard, early and rapid detection of …

Plasmonic properties of colloidal assemblies

C Rossner, TAF König, A Fery - Advanced Optical Materials, 2021 - Wiley Online Library
The assembly of metal nanoparticles into supracolloidal structures unlocks optical features,
which can go beyond synergistic combinations of the properties of their primary building …

Engineering micro–nanomaterials for biomedical translation

Y Chen, M Alba, T Tieu, Z Tong… - Advanced …, 2021 - Wiley Online Library
Engineered nano–bio interfaces–driven by vertical micro/nanoneedles, nanoparticles, organ‐
on‐chip devices, and a diversity of nanosubstrates for mass spectroscopy imaging–are …

Toward glycomaterials with selectivity as well as affinity

SJ Richards, MI Gibson - JACS Au, 2021 - ACS Publications
Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity
toward carbohydrate binding proteins (eg, lectins) due to the nonlinear enhancement from …

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

SJ Richards, T Keenan, JB Vendeville… - Chemical …, 2021 - pubs.rsc.org
Galectins are potential biomarkers and therapeutic targets. However, galectins display
broad affinity towards β-galactosides meaning glycan-based (nano) biosensors lack the …