Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy affecting many
different body tissues, predominantly skeletal and cardiac muscles and the central nervous …

Myotonic dystrophy type 1 (DM1) is one of the most common muscular dystrophies and can
be potentially treated with antisense therapy decreasing mutant DMPK, targeting miRNAs or …

Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1
(DM1); however, the underlying molecular mechanism and the impact on the disease …

Background Myotonic dystrophy type 1 results from an RNA gain-of-function mutation, in
which DM1 protein kinase (DMPK) transcripts carrying expanded trinucleotide repeats exert …

Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy affecting adults and
children, is a multi-systemic disorder affecting skeletal, cardiac, and smooth muscles as well …

Myotonic dystrophy (DM) is caused by expansions of C (C) TG repeats in the non-coding
regions of the DMPK and CNBP genes, and DM patients often suffer from sudden cardiac …

Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and
myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and …

Loss of gene function can be compensated by paralogs with redundant functions. An
example of such compensation are the paralogs of the Muscleblind-Like (MBNL) family of …

Myotonic dystrophy type 1 is a dominantly inherited multisystemic disease caused by CTG
tandem repeat expansions in the DMPK 3′ untranslated region. These expanded repeats …

Abstract Myotonic Dystrophy Type 1 (DM1) is an autosomal dominant multisystemic disorder
for which cardiac features, including conduction delays and arrhythmias, are the second …