The RUNX genes have come to prominence recently because of their roles as essential
regulators of cell fate in development and their paradoxical effects in cancer, in which they …

Myeloid malignancies are clonal disorders that are characterized by acquired somatic
mutation in hematopoietic progenitors. Recent advances in our understanding of the genetic …

Abstract Nur77 (NR4A1) and Nor-1 (NR4A3) are highly homologous orphan nuclear
receptors, that regulate the transcription of overlapping target genes,. The transcriptional …

Monosomy 7 and interstitial deletion of 7q (− 7/7q−) are well-recognized nonrandom
chromosomal abnormalities frequently found among patients with myelodysplastic …

Epigenetic regulators, such as EZH2, are frequently mutated in cancer, and loss-of-function
EZH2 mutations are common in myeloid malignancies. We have examined the importance …

BCR/ABL-kinase mutations frequently mediate clinical resistance to the selective tyrosine
kinase inhibitor Imatinib mesylate (IM, Gleevec®). However, mechanisms that promote …

Leukemia, specifically acute myeloid leukemia (AML), is a common malignancy that can be
differentiated into multiple subtypes based on leukemogenic history and etiology. Although …

Summary The t (8; 21) and inv (16) chromosomal aberrations generate the oncoproteins
AML1-ETO (AE) and CBFβ-SMMHC (CS). The role of these oncoproteins in acute myeloid …

Acute myeloid leukemia (AML) is the most common form of adult leukemia. The transcription
factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy …

It is hard today, in 2008, when genetic changes in cancer and specifically hematologic
malignancies are accepted as central players, to look back 50 years and realize how …