Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

R Bai, J Guo, XY Ye, Y Xie, T Xie - Ageing research reviews, 2022 - Elsevier
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

ROS scavenging Mn 3 O 4 nanozymes for in vivo anti-inflammation

J Yao, Y Cheng, M Zhou, S Zhao, S Lin, X Wang… - Chemical …, 2018 - pubs.rsc.org
Reactive oxygen species (ROS)-induced oxidative stress is linked to various diseases,
including cardiovascular disease and cancer. Though highly efficient natural ROS …

Oxidant mechanisms in renal injury and disease

BB Ratliff, W Abdulmahdi, R Pawar… - Antioxidants & redox …, 2016 - liebertpub.com
Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Diabetes, oxidative stress and therapeutic strategies

L Rochette, M Zeller, Y Cottin, C Vergely - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Diabetes has emerged as a major threat to health worldwide. Scope of Review
The exact mechanisms underlying the disease are unknown; however, there is growing …

Free radicals and antioxidants: updating a personal view

B Halliwell - Nutrition reviews, 2012 - academic.oup.com
This article looks back to the antioxidant/free radical field in 1994 and discusses how it has
progressed in the past 18 years. In some areas, there has been little change: the role of …

Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity

Z Chen, JJ Yin, YT Zhou, Y Zhang, L Song, M Song… - ACS …, 2012 - ACS Publications
Iron oxide nanoparticles (IONPs) are frequently used in biomedical applications, yet their
toxic potential is still a major concern. While most studies of biosafety focus on cellular …

Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

E Lubos, J Loscalzo, DE Handy - 2011 - liebertpub.com
Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Recent advances in electrochemical sensing for hydrogen peroxide: a review

W Chen, S Cai, QQ Ren, W Wen, YD Zhao - Analyst, 2012 - pubs.rsc.org
Due to the significance of hydrogen peroxide (H2O2) in biological systems and its practical
applications, the development of efficient electrochemical H2O2 sensors holds a special …