Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Photodynamic nanomedicine in the treatment of solid tumors: perspectives and challenges

A Master, M Livingston, AS Gupta - Journal of controlled release, 2013 - Elsevier
Photodynamic therapy (PDT) is a promising treatment strategy where activation of
photosensitizer drugs with specific wavelengths of light results in energy transfer cascades …

Delivery of the photosensitizer Pc 4 in PEG–PCL micelles for in vitro PDT studies

AM Master, ME Rodriguez, ME Kenney… - Journal of …, 2010 - Elsevier
The silicon phthalocyanine Pc 4 is a second-generation photosensitizer that has several
properties superior to other photosensitizers currently approved by the FDA, and it has …

Structural Factors and Mechanisms Underlying the Improved Photodynamic Cell Killing with Silicon Phthalocyanine Photosensitizers Directed to Lysosomes Versus …

ME Rodriguez, P Zhang, K Azizuddin… - Photochemistry and …, 2009 - Wiley Online Library
The phthalocyanine photosensitizer Pc 4 has been shown to bind preferentially to
mitochondrial and endoplasmic reticulum membranes. Upon photoirradiation of Pc 4 …

EGFR-mediated intracellular delivery of Pc 4 nanoformulation for targeted photodynamic therapy of cancer: in vitro studies

AM Master, Y Qi, NL Oleinick, AS Gupta - … : Nanotechnology, Biology and …, 2012 - Elsevier
In photodynamic therapy (PDT), the light activation of a photosensitizer leads to the
generation of reactive oxygen species that can trigger various mechanisms of cell death …

Amphiphilic phthalocyanines in polymeric micelles: A supramolecular approach toward efficient third-generation photosensitizers

F Setaro, JWH Wennink, PI Mäkinen… - Journal of Materials …, 2020 - pubs.rsc.org
In this paper we describe a straightforward supramolecular strategy to encapsulate silicon
phthalocyanine (SiPc) photosensitizers (PS) in polymeric micelles made of poly (ε …

Potential of porous silicon nanoparticles as an emerging platform for cancer theranostics

V Stojanovic, F Cunin, JO Durand, M Garcia… - Journal of Materials …, 2016 - pubs.rsc.org
Currently, nanoscience is a major part of biomedical research, due to material advances that
aid the development of new tools and techniques to replace traditional methods. To this end …

Optimization of a nanomedicine-based silicon phthalocyanine 4 photodynamic therapy (Pc 4-PDT) strategy for targeted treatment of EGFR-overexpressing cancers

AM Master, M Livingston, NL Oleinick… - Molecular …, 2012 - ACS Publications
The current clinical mainstays for cancer treatment, namely, surgical resection,
chemotherapy, and radiotherapy, can cause significant trauma, systemic toxicity, and …

Real-time, in vivo measurement of tissular through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

F Piffaretti, AM Novello, RS Kumar… - … of biomedical optics, 2012 - spiedigitallibrary.org
Tissular oxygen concentration plays a key role during photodynamic therapy (PDT).
Therefore, monitoring its local oxygen partial pressure (pO 2) may help predict and/or control …

Observation and Photophysical Characterization of Silicon Phthalocyanine J‐Aggregate Dimers in Aqueous Solutions

T Doane, A Chomas, S Srinivasan… - Chemistry–A European …, 2014 - Wiley Online Library
The use of macrocyclic molecules for both imaging and photodynamic therapy (PDT) has
proven to be a powerful method for assessing and treating diseases, respectively. However …