The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon
degeneration and a therapeutic target for several neurodegenerative conditions. We show …

During axon degeneration, NAD+ levels are largely controlled by two enzymes:
nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and sterile alpha and toll …

Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …

Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …

Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal
Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen …

Animals integrate developmental and nutritional signals before committing crucial resources
to growth and reproduction; however, the pathways that perceive and respond to these …

Precursors of nicotinamide adenine dinucleotide (NAD+), modulators of enzymes of the
NAD+ biosynthesis pathways and inhibitors of NAD+ consuming enzymes, are the main …

The COVID-19 pandemic reminds us that in spite of the scientific progress in the past
century, there is a lack of general antiviral strategies. In analogy to broad-spectrum …

Growth and destruction are central components of the neuronal injury response. Injured
axons that are capable of repair, including axons in the mammalian peripheral nervous …

Innate immunity in bacteria, plants, and animals requires the specialized subset of
Toll/interleukin-1/resistance gene (TIR) domain proteins that are nicotinamide adenine …